Allergy & Immunology
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Regulation of id2 expression in el4 t lymphoma cells overexpressing growth hormone.
Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone. Cell Immunol. 2008 Nov 14; Authors: Weigent DA In previous studies, we have shown that overexpression of growth hormone (GH) in cells of the immune system upregulates proteins involved in cell growth and protects from apoptosis. Here, we report that overexpression of GH in EL4 T lymphoma cells (GHo) also significantly increased levels of the inhibitor of differentiation-2 (Id2). The increase in Id2 was suggested in both Id2 promoter luciferase assays and by Western analysis for Id2 protein. To identify the regulatory elements that mediate transcriptional activation by GH in the Id2 promoter, promoter deletion analysis was performed. Deletion analysis revealed that transactivation involved a 301-...
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Effector and suppressor roles for lfa-1 during the development of experimental autoimmune encephalomyelitis.
Effector and suppressor roles for LFA-1 during the development of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2008 Nov 14; Authors: Dugger KJ, Zinn KR, Weaver C, Bullard DC, Barnum SR LFA-1 (CD11a/CD18) is a member of the beta(2)-integrin family of adhesion molecules important in leukocyte trafficking and activation. Although LFA-1 is thought to contribute to the development of experimental autoimmune encephalomyelitis (EAE) primarily through its functions on effector T cells, its importance on other leukocyte populations remains unexplored. To address this question, we performed both adoptive transfer EAE experiments involving CD11a(-/-) mice and trafficking studies using bioluminescent T cells expressing luciferase under the control of a CD2 promoter (T-lux cel...
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Last listing added: 11/19/08
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